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FEATURES

DESCRIPTION

Also known as POF14_SCHPO, pof14. Expression is induced during oxidative stress. Plays an essential, SCF-independent, role in the stress response to hydrogen peroxide for survival, by negatively regulating ergosterol synthesis via direct binding to the squalene synthase erg9. Component of the E3 ubiquitin ligase Skp1-Cullin-1-F-box (SCF) complex. Interacts with skp1, cul1 and erg9.

Also known as POF14_SCHPO, pof14. Expression is induced during oxidative stress. Plays an essential, SCF-independent, role in the stress response to hydrogen peroxide for survival, by negatively r ...

EXTERNAL LINKS

uniprot
enzyme classification

pof14

F-box protein pof14

Structural Ligandability

Domains Chains

Distribution

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