FEATURES

FAMILY

DESCRIPTION

Also known as SDHF2_SCHPO, emi5. Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. Interacts with the flavoprotein subunit within the SDH catalytic dimer.

EXTERNAL LINKS

uniprot
enzyme classification

emi5

Succinate dehydrogenase assembly factor 2, mitochondrial

emi5

Structural Ligandability

Domains Chains

Distribution