elt-2 (Transcription factor elt-2)
FEATURES
Loading...
Loading...
ORGANISM
Caenorhabditis elegans
DESCRIPTION
Also known as ELT2_CAEEL, elt-2. Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' (PubMed:7782329, PubMed:15733671, PubMed:18003741, PubMed:18024960, PubMed:18448117, PubMed:26700680, PubMed:26016853). Predominantly directs the transcription of intestinal genes such as ges-1, cpr-6, pho-1, ftn-1 and lev-11, and itself (PubMed:9659934, PubMed:10518545, PubMed:15733671, PubMed:18448117, PubMed:19111532, PubMed:26700680). Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-7 to control normal gene expression and promote normal formation of the intestine (PubMed:20807527). Regulates intestinal gene expression in response to hypoxia to promote longevity (PubMed:25284791). Regulates tissue specific gene expression at basal levels and in response to bacterial infection in the intestine to control innate immununity (PubMed:16968778, PubMed:21168435, PubMed:25340560, PubMed:26016853). Plays a role in the induction of metal-responsive genes, activating gene expression from zinc-activated promoters and iron-dependent promoters and enhancers (PubMed:18024960, PubMed:22194696, PubMed:25552416). May regulate the expression of genes that control sensitivity to oxidative stress, in a mab-3-dependent manner, and osmotic stress, in conjunction with the GATA region-binding transcription factor elt-3 (PubMed:17901115, PubMed:20498281, PubMed:20126308). May play a role in sphingolipid signaling by regulating the expression of the sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735). May act with the Notch signaling pathway to promote endodermal gene expression (PubMed:18003741). Has a protective role in response to infection by Gram-negative bacteria such as S.enterica, E.coli, P.aeruginosa and B.pseudomallei, Gram-positive bacterium E.faecalis and fungal pathogen C.neoformans (PubMed:16968778, PubMed:17183709, PubMed:21168435, PubMed:23980181, PubMed:30265660). An association with the 26S proteasome regulatory subunit rpt-6, in part, controls gene expression in response to infection by P.aeruginosa (PubMed:30265660). Regulates gene expression during the recovery phase following a bacterial infection (PubMed:25340560, PubMed:30265660). May act with p38-activated transcription factors to control p38 gene induction in response to bacterial infection (PubMed:22967128, PubMed:26016853). Controls lysosome formation in the intestine by controlling lysosomal gene expression (PubMed:26828939). Interacts with lag-1 (PubMed:18003741). Interacts with pha-4 (PubMed:18448117). Interacts with rpt-6 (PubMed:30265660).
Also known as ELT2_CAEEL, elt-2. Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' (PubMed:7782329, PubMed:15733671, PubMed:18003741, PubMed:18024960, PubMed:18448117, PubMed:26700680, PubMed:26016853). Predominantly directs the transcription of intestinal genes such as ges-1, cpr-6, pho-1, ftn-1 and lev-11, and itse
elt-2 logo

elt-2

Transcription factor elt-2

Molecular Synopsis