FEATURES

FAMILY

DESCRIPTION

Also known as ARF12_CAEEL, arf-1.2, arf-1. GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Involved in endoplasmic reticulum dynamics during embryogenesis (PubMed:15716356). Also required for adult germline function (PubMed:15576487). Plays a role in cell shedding during embryogenesis probably by promoting the endocytosis of cell adhesion molecules (PubMed:22801495). During neurogenesis, involved in cell autonomous Q.p neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, probably by controlling endocytosis (PubMed:21596567). Plays a role in maintaining mitochondrial morphology (PubMed:25190516).

arf-1.2

Structural Ligandability

Domains Chains

Distribution