FEATURES

DESCRIPTION

Also known as WRM1_CAEEL, wrm-1. Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Component of the beta-catenin-lit-1 complex which promotes phosphorylation, down-regulation and subcellular relocation of pop-1 (PubMed:10380924). Within the complex, activates lit-1-dependent kinase activity (PubMed:10380924). Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome positioning and can activation transcription in yeast. Involved in the development of distal tip cells (DTC) by regulating the asymmetric distribution of cye-1 and cki-1 between the daughters of Z1.a and Z4.p cells (PubMed:17476329). Interacts (independently of ARM repeat) with nhr-25 (PubMed:16890160). Component of the beta-catenin-lit-1 complex (also called the lit-1/wrm-1 complex or the wrm-1/lit-1 kinase complex) at least composed of lit-1 and wrm-1 (PubMed:10380924, PubMed:15066285). Interacts (via N-terminus) with lit-1; the interaction is direct and activates lit-1 kinase activity which leads to the phosphorylation of pop-1 (PubMed:10380924, PubMed:11560894, PubMed:15066285). This promotes pop-1 interaction with par-5 and translocation of pop-1 from the nucleus to the cytoplasm (PubMed:15066285).

EXTERNAL LINKS

wrm-1

Armadillo repeat-containing protein wrm-1

wrm-1

Molecular Synopsis