FEATURES

DESCRIPTION

Also known as DCN1_YEAST, DCN1. Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with HRT1/RBX1 to recruit the Nedd8-charged E2 UBC12 to the cullin component of SCF-type complexes. Interacts with the cullin CDC53. Interacts with ubiquitin via its UBA-like domain. Interacts with RUB1/NEDD8.

EXTERNAL LINKS

uniprot
enzyme classification

DCN1

Defective in cullin neddylation protein 1

DCN1

Molecular Synopsis