FEATURES

DESCRIPTION

Also known as NSI1_YEAST, NSI1. DNA-binding protein that recognizes sequence-specific replication termini (Ter sites) within rDNA (PubMed:14576157). Binds to rDNA terminator elements and mediates efficient RNA polymerase I transcription termination (PubMed:22805593). Required for rDNA silencing at the non-transcribed spacer 1 (NTS1). Promotes the association of SIR2 with NTS1 and contributes to maintenance of rDNA stability (PubMed:22362748). Interacts with FOB1 (PubMed:14576157, PubMed:22362748). Interacts with the RENT complex subunits NET1 and SIR2 (PubMed:22362748).

EXTERNAL LINKS

uniprot
enzyme classification

NSI1

RNA polymerase I termination factor

NSI1

Molecular Synopsis