FEATURES

FAMILY

DESCRIPTION

Also known as IF6_YEAST, TIF6, CDC95. Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by the GTPase RIA1/EFL1 and by SDO1. Also required for pre-rRNA processing. Monomer. Associates with the 60S ribosomal subunit.

EXTERNAL LINKS

uniprot
enzyme classification

TIF6

Eukaryotic translation initiation factor 6

TIF6

Molecular Synopsis