FEATURES

FAMILY

DESCRIPTION

Also known as TRAP1_HUMAN, TRAP1, HSP75. Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with SRC. Interacts with SDHA.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TRAP1

Mutations

Mutation(s) distribution

Mutations table