FEATURES

FAMILY

DESCRIPTION

Also known as MTAP_HUMAN, MTAP, MSAP. Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. Homotrimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MTAP

S-methyl-5'-thioadenosine phosphorylase

Mutations

Mutation(s) distribution

Mutations table

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