FEATURES

FAMILY

cyclic nucleotide phosphodiesterase family

DESCRIPTION

Also known as PDE3B_HUMAN, PDE3B. Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. Interacts with PIK3CG (By similarity). Interacts with RAPGEF3 and PIK3R6.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PDE3B

cGMP-inhibited 3', 5'-cyclic phosphodiesterase B

PDE3B

Molecular Synopsis