FEATURES

FAMILY

DESCRIPTION

Also known as TRPC3_HUMAN, TRPC3, TRP3. Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1, 4, 5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. Interacts with ITPR1 (PubMed:9853757). Interacts with ITPR3 (PubMed:10611319). Interacts with MX1 (PubMed:15757897). Interacts with RNF24 (PubMed:17850865). Interacts with JPH2; the interaction is involved in maintaining Ca(2+) homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation (PubMed:20095964).

EXTERNAL LINKS

TRPC3

Short transient receptor potential channel 3

TRPC3

Molecular Synopsis