FEATURES

FAMILY

DESCRIPTION

Also known as ULA1_HUMAN, NAE1, APPBP1. Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. Heterodimer of UBA3 and NAE1. The complex binds NEDD8 and UBE2M. Binds APP and TP53BP2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NAE1

NEDD8-activating enzyme E1 regulatory subunit

NAE1

Molecular Synopsis