FEATURES

FAMILY

DESCRIPTION

Also known as BMPR2_HUMAN, BMPR2, PPH1. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Interacts with GDF5 (PubMed:21976273). Interacts with BMP4 (PubMed:29212066).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

BMPR2

Mutations

Mutation(s) distribution

Mutations table