FEATURES

FAMILY

DESCRIPTION

Also known as COTL1_HUMAN, COTL1, CLP. Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. Interacts with 5-lipoxygenase (ALOX5/5LO) in a calcium-independent manner. Binds to F-actin with a stoichiometry of 1:2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

COTL1

Coactosin-like protein

Mutations

Mutation(s) distribution

Mutations table

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