FEATURES

FAMILY

cyclic nucleotide phosphodiesterase family

DESCRIPTION

Also known as PDE1C_HUMAN, PDE1C. Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8557689, PubMed:29860631). Has a high affinity for both cAMP and cGMP (PubMed:8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). Homodimer.

EXTERNAL LINKS

PDE1C

Calcium/calmodulin-dependent 3', 5'-cyclic nucleotide phosphodiesterase 1C

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

PDE1C

Structural Ligandability

Domains Chains

Distribution