FEATURES

FAMILY

DESCRIPTION

Also known as DYHC1_HUMAN, DYNC1H1, DHC1, DNCH1, DNCL, DNECL, DYHC, KIAA0325. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and dynein LCs assemble on the IC dimer. Interacts with DYNC1LI1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with DYNC1LI2; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with DYNC1I2 (By similarity). Interacts with BICD2 (PubMed:25512093). Interacts with isoform 2 of CRACR2A (PubMed:31092558).

Also known as DYHC1_HUMAN, DYNC1H1, DHC1, DNCH1, DNCL, DNECL, DYHC, KIAA0325. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along mic ...

EXTERNAL LINKS

DYNC1H1

Mutations

Mutation(s) distribution

Mutations table