FEATURES

FAMILY

DESCRIPTION

Also known as GRM2_HUMAN, GRM2, GPRC1B, MGLUR2. G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Interacts with TAMALIN (By similarity). Interacts with HTR2A.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GRM2

Mutations

Mutation(s) distribution

Mutations table