FEATURES

FAMILY

ornithine cyclodeaminase/mu-crystallin family

DESCRIPTION

Also known as CRYM_HUMAN, CRYM, THBP. Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CRYM

Ketimine reductase mu-crystallin

CRYM

Molecular Synopsis