FEATURES

DESCRIPTION

Also known as FRPD4_HUMAN, FRMPD4, KIAA0316, PDZD10, PDZK10. Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4, 5-bisphosphate. Interacts (via C-terminus) with DLG1, DLG2, DLG3 and DLG4/PSD95. Interacts (via N-terminus) with ARHGEF7; the interaction is mediated by the PDZ domain (PubMed:19118189). Interacts with GPSM2 (via TPR repeat region) (PubMed:25664792).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FRMPD4

FERM and PDZ domain-containing protein 4

FRMPD4

Molecular Synopsis