FEATURES

FAMILY

DESCRIPTION

Also known as CND2_HUMAN, NCAPH, BRRN, BRRN1, CAPH, KIAA0074. Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.

Also known as CND2_HUMAN, NCAPH, BRRN, BRRN1, CAPH, KIAA0074. Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense ch ...

EXTERNAL LINKS

NCAPH

Mutations

Mutation(s) distribution

Mutations table