FEATURES

DESCRIPTION

Also known as PAF15_HUMAN, PCLAF, KIAA0101, NS5ATP9, PAF. PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. Interacts (when monoubiquitinated at Lys-15 and Lys-24) with PCNA. Interacts with isoform 2/p33ING1b of ING1. Interacts with BRCA1.

Also known as PAF15_HUMAN, PCLAF, KIAA0101, NS5ATP9, PAF. PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is di ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PCLAF

PCNA-associated factor

PCLAF

Molecular Synopsis