FEATURES

DESCRIPTION

Also known as EEA1_HUMAN, EEA1, ZFYVE2. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding. Interacts with RAB31. Interacts with ERBB2. Interacts with SAMD9 AND SAMD9L (PubMed:24029230). May interact with PLEKHF2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

EEA1

Early endosome antigen 1

EEA1

Molecular Synopsis