FEATURES

FAMILY

DESCRIPTION

Also known as RHEB_HUMAN, RHEB, RHEB2. Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. Binds to mTORC1 in a guanyl nucleotide-independent manner. Interacts directly with MTOR, MLST8 and RPTOR. Interacts with TSC2. Interacts (when prenylated) with PDE6D; this promotes release from membranes.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RHEB

GTP-binding protein Rheb

RHEB

Molecular Synopsis