RHEB (GTP-binding protein Rheb)

FEATURES

FAMILY

DESCRIPTION

Also known as RHEB_HUMAN, RHEB, RHEB2. Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. Binds to mTORC1 in a guanyl nucleotide-independent manner. Interacts directly with MTOR, MLST8 and RPTOR. Interacts with TSC2. Interacts (when prenylated) with PDE6D; this promotes release from membranes.

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EXTERNAL LINKS

RHEB

GTP-binding protein Rheb

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

RHEB

Molecular Synopsis