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FEATURES

FAMILY

3-beta-HSD family

DESCRIPTION

Also known as NSDHL_HUMAN, NSDHL, H105E3. Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis (By similarity). Plays also a role in the regulation of the endocytic trafficking of EGFR (By similarity). Homodimer.

Also known as NSDHL_HUMAN, NSDHL, H105E3. Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis (By ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NSDHL

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

Mutations

Mutation(s) distribution

Mutations table

Search Mutation

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