FEATURES

FAMILY

dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family

DESCRIPTION

Also known as AAAT_HUMAN, SLC1A5, ASCT2, M7V1, RDR, RDRC. Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519, PubMed:29872227). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904)., (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114., (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus., (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. Homotrimer (Probable) (PubMed:29872227). Interacts with ERVH48-1/suppressyn; may negatively regulate syncytialization (PubMed:23492904).

Also known as AAAT_HUMAN, SLC1A5, ASCT2, M7V1, RDR, RDRC. Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It acce ...

EXTERNAL LINKS

SLC1A5

Mutations

Mutation(s) distribution

Mutations table