FEATURES

FAMILY

glutamate-gated ion channel (TC 1.A.10.1) family

DESCRIPTION

Also known as GRIK5_HUMAN, GRIK5, GRIK2. Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S, 3R-ACPD. Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GRIK5

Glutamate receptor ionotropic, kainate 5

GRIK5

Molecular Synopsis