FEATURES

FAMILY

cation transport ATPase (P-type) (TC 3.A.3) family

DESCRIPTION

Also known as AT2B3_HUMAN, ATP2B3. ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals (PubMed:25953895, PubMed:27035656, PubMed:22912398, PubMed:18029012). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:25953895, PubMed:27035656). May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established (By similarity). Interacts with PDZD11 (PubMed:12763866). Interacts (via N-terminus) with YWHAE (PubMed:18029012).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ATP2B3

Plasma membrane calcium-transporting ATPase 3

ATP2B3

Molecular Synopsis