FEATURES

FAMILY

glutaminyl-peptide cyclotransferase family

DESCRIPTION

Also known as QPCT_HUMAN, QPCT. Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

QPCT

Glutaminyl-peptide cyclotransferase

QPCT

Molecular Synopsis