FEATURES

FAMILY

DESCRIPTION

Also known as KGUA_HUMAN, GUK1, GMK, GMPK. Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664). Monomer (PubMed:31201273). Interacts with RD3 (PubMed:29515371).

EXTERNAL LINKS

GUK1

Guanylate kinase

GUK1

Molecular Synopsis