FEATURES

FAMILY

DESCRIPTION

Also known as DGUOK_HUMAN, DGUOK, DGK. Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:8692979, PubMed:8706825, PubMed:11687801, PubMed:17073823, PubMed:23043144). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DGUOK

Deoxyguanosine kinase, mitochondrial

Mutations

Mutation(s) distribution

Mutations table

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