FEATURES

FAMILY

DESCRIPTION

Also known as MTP_EBVA8, BNRF1. Tegument protein that plays a role in the inhibition of host intrinsic defenses to promote viral early gene activation. Interacts with host DAXX and thereby disrupts the complex between DAXX and ATRX. Suppresses the DAXX-ATRX dependent deposition of histone H3.3 on viral chromatin allowing viral transcription. May also play a role in virus entry at attachment or membrane fusion steps. Interacts with host DAXX; this interaction disrupts the chromatin remodeling complex ATRX:DAXX and thus allows viral transcription.

EXTERNAL LINKS

uniprot
enzyme classification

BNRF1

Major tegument protein

BNRF1

Molecular Synopsis