FEATURES

FAMILY

DESCRIPTION

Also known as SPY1_CEREL, SPRY1. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). Forms heterodimers with SPRY2 (By similarity). Interacts with TESK1 (By similarity). Interacts with CAV1 (via C-terminus) (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

SPRY1

Protein sprouty homolog 1

SPRY1

Structural Ligandability

Domains Chains

Distribution