FEATURES

FAMILY

DESCRIPTION

Also known as PA2B1_VIPBN, PA2B1. Heterodimer: shows the same activities as the monomer, but with a lower potency., Monomer: snake venom phospholipase A2 (PLA2) that shows presynaptic neurotoxicity, anticoagulant activity and that weakly inhibits ADP-induced platelet aggregation (PubMed:18083205). Inhibits exocytosis in pancreatic beta cells, confirming it can act presynaptically in inhibiting the exocytosis of neurotransmitters in neurons (PubMed:19500614). PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Heterodimer; non-covalently linked. The toxic basic protein has phospholipase A2 activity (chain HDP-1P) and the non-toxic acidic protein functions as its inhibitor (chain HPD-1I (AC A4VBF0)).

EXTERNAL LINKS

PA2B1

Basic phospholipase A2 chain HDP-1P

PA2B1

Molecular Synopsis