FEATURES

FAMILY

amiloride-sensitive sodium channel (TC 1.A.6) family

DESCRIPTION

Also known as ASIC1_CHICK, ASIC1, ACCN2. Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Homotrimer. Interacts with spider venom psalmotoxin 1 with a one to one stoichiometry. Interacts with the heterodimeric snake venom neurotoxin composed of MitTx-alpha and MitTx-beta.

EXTERNAL LINKS

ASIC1

Mutations

Mutation(s) distribution

Mutations table