FEATURES

DESCRIPTION

Also known as VG_DROME, vg. Involved in determining which thoracic imaginal disk cells will form wings and halteres, perhaps by interacting with other nuclear regulatory proteins. When in combination with scalloped (sd), it acts as a transcriptional activation complex that regulates gene expression in the wing. Binding to sd switches the DNA target selectivity of sd. Required and sufficient for cell proliferation at the dorsal/ventral (D/V) boundary of the wing imaginal disk. Also required for cell proliferation in the wing imaginal disk, mediated via activation of E2f. By interacting with Dhfr, may control genes involved in DNA replication. The Ser-rich protein domain within the C-terminal region interacts with the C-terminus of sd to form a complex which acts as a selector for wing development. Interacts with Dhfr.

EXTERNAL LINKS

vg

Protein vestigial

vg

Molecular Synopsis