FEATURES

FAMILY

DESCRIPTION

Also known as IUNH_CRIFA, IUNH. Catalyzes the hydrolysis of the N-glycosidic bond of commonly occurring purine and pyrimidine nucleosides into ribose and the base, but has a preference for inosine and uridine as substrates. Is not active on thymidine and 2'-deoxynucleosides. Functions in purine salvage from the blood of the host, a fundamental pathway since protozoan parasites such as C.fasciculata are incapable of de novo purine biosynthesis. Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification

IUNH

Inosine-uridine preferring nucleoside hydrolase

Mutations

Mutation(s) distribution

Mutations table

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