FEATURES

FAMILY

serine-aspartate repeat-containing protein (SDr) family

DESCRIPTION

Also known as CLFB_STAA8, clfB. Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps. Partly responsible for mediating bacterial attachment to the highly keratinized squamous epithelial cells from the nasal cavity via an interaction with cytokeratin K10 (K10). Also promotes bacterial attachment to cultured keratinocytes, possibly through an interaction with cytokeratin K10. Binds mouse cytokeratin K10. Activates human platelet aggregation.

EXTERNAL LINKS

uniprot
enzyme classification

clfB

Clumping factor B

clfB

Molecular Synopsis