FEATURES

FAMILY

DESCRIPTION

Also known as ESSD_STAA8, essD, esaD. Component of the type VII secretion system (Ess). Plays a role in Ess secretion during infection. Required for the efficient secretion of EsxA. Required for abscess formation and staphylococcal persistence in host tissues (By similarity). Possesses a toxic DNase activity that is modulated by EssG by forming a nuclease toxin-antitoxin pair. This nuclease toxin targets competitor bacteria (PubMed:27723728). Interacts (via C-terminal) with EssG; this interaction blocks EssD activity (PubMed:27723728). Interacts with EssE (PubMed:27723728).

EXTERNAL LINKS

uniprot
enzyme classification

essD

Type VII secretion system protein EssD

essD

Structural Ligandability

Domains Chains

Distribution