FEATURES

FAMILY

DESCRIPTION

Also known as PERR_STAA8, perR. Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. Regulates expression of genes encoding antioxidant proteins, such as katA, ahpCF, bcp and trxB. Also regulates expression of the iron-storage protein ftn, the ferritin-like protein mrgA, the ferric uptake regulator fur, the manganese transporter operon mntABC, and its own expression. May act as a hydrogen peroxide and organic hydroperoxide sensor. Required for full virulence in a murine skin abscess model of infection.

EXTERNAL LINKS

uniprot
enzyme classification

perR

Peroxide-responsive repressor PerR

perR

Molecular Synopsis