FEATURES

FAMILY

DESCRIPTION

Also known as ASHH2_ARATH, ASHH2, EFS, LAZ2, SDG8, SET8. Histone methyltransferase involved in di and tri-methylation of 'Lys-36' of histone H3 (H3K36me2 and H3K36me3). Binds to H3 already mono- or di-methylated on 'Lys-4'(H3K4me1 or H3K4me2), but not to H3K4me3. H3K4me and H3K36me represent specific tags for epigenetic transcriptional activation. Regulates positively FLC transcription to prevent early flowering transition. Required for flowering transition in response to vernalization and for the maintenance of FLC expression in late embryos, but dispensable for the initial reactivation in early embryos during reprogramming. Seems also to modulate several traits including floral organ size, root size and dormancy. Promotes apical dominance (PubMed:16299497, PubMed:10518493, PubMed:16258034, PubMed:18070919, PubMed:19915673, PubMed:20711170). Directly involved in the tri-methylation of 'Lys-36' of histone H3 (H3K36me3) at LAZ5 chromatin to maintain a transcriptionally active state of LAZ5, a TIR-NB-LRR protein involved in innate immunity (PubMed:20949080). Required for brassinosteroid (BR)-induced gene expression and histone H3 trimethylation on 'Lys-36' (H3K36me3) in BR-regulated genes (PubMed:24838002). Interacts with FRI and SUF4, two components of the transcription activator complex FRI-C, and with SWC6, a component of the SWR1 chromatin-remodeling complex (PubMed:20711170, PubMed:21282526, PubMed:21522130). Interacts with BZR2/BES1 and IWS1 (PubMed:24838002).

Also known as ASHH2_ARATH, ASHH2, EFS, LAZ2, SDG8, SET8. Histone methyltransferase involved in di and tri-methylation of 'Lys-36' of histone H3 (H3K36me2 and H3K36me3). Binds to H3 already mono- ...

EXTERNAL LINKS

ASHH2

Mutations

Mutation(s) distribution

Mutations table