FEATURES

FAMILY

DESCRIPTION

Also known as RRAAH_HAHCH, HCH_02125. Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity). Homotrimer.

EXTERNAL LINKS

uniprot
enzyme classification

HCH_02125

Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase

HCH_02125

Structural Ligandability

Domains Chains

Distribution