FEATURES

FAMILY

DESCRIPTION

Also known as NANM_SHIBS, nanM. Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

nanM

N-acetylneuraminate epimerase

nanM

Structural Ligandability

Domains Chains

Distribution