FEATURES

FAMILY

DESCRIPTION

Also known as TRM5_HUMAN, TRMT5, KIAA1393, TRM5. Involved in mitochondrial tRNA methylation (PubMed:26189817). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TRMT5

tRNA (guanine(37)-N1)-methyltransferase

TRMT5

Molecular Synopsis