DHSc (Deoxyhypusine synthase)

FEATURES

ORGANISM

Trypanosoma brucei brucei (strain 927/4 GUTat10.1)

FAMILY

DESCRIPTION

Also known as DHYSC_TRYB2, DHSc. In association with the non-catalytic regulatory subunit DHSp, catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF5A precursor protein to form the intermediate deoxyhypusine residue. Regulates protein levels of its regulatory subunit DHSp. Required for cell growth and survival. Heterotetramer formed by a homodimer of the non-catalytic regulatory subunit DHSp and a homodimer of the catalytic subunit DHSc where DHSc appears to bind spermidine and DHSp appears to bind NAD(+).

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EXTERNAL LINKS

DHSc

Deoxyhypusine synthase

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

DHSc

Molecular Synopsis