FEATURES

FAMILY

DESCRIPTION

Also known as MAJIN_HUMAN, MAJIN, C11orf85. Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane. Component of the MAJIN-TERB1-TERB2 complex, composed of MAJIN, TERB1 and TERB2.

EXTERNAL LINKS

MAJIN

Membrane-anchored junction protein

MAJIN

Molecular Synopsis