FEATURES

DESCRIPTION

Also known as ARHGG_MOUSE, Arhgef16. Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 (By similarity). Interacts with ELMO2, EPHA2, RAC1 and RHOG; mediates activation of RAC1 by EPHA2. Interacts with TAX1BP3 (via PDZ domain) (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

Arhgef16

Rho guanine nucleotide exchange factor 16

Arhgef16

Molecular Synopsis