FEATURES

FAMILY

DESCRIPTION

Also known as TNR6A_MOUSE, Tnrc6a, Kiaa1460. Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:22187428). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:22187428). As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes (By similarity). Interacts with AGO2. Interacts with AGO1, AGO3 and AGO4. Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex. Interacts with ZC3H12A. Interacts with SND1. Interacts with GARRE1 (By similarity).

EXTERNAL LINKS

Tnrc6a

Structural Ligandability

Domains Chains

Distribution