FEATURES

FAMILY

DESCRIPTION

Also known as SPAG8_MOUSE, Spag8. Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (PubMed:20488182). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (PubMed:17187156). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (By similarity). May play a role in fertility and microtubule formation through interaction with RANBP9 (By similarity). Interacts with FHL5 (via second LIM domain) (PubMed:20488182). Interacts with RANBP9 (By similarity).

Spag8

Structural Ligandability

Domains Chains

Distribution